Amelia Sachs: rookie beat cop in New York City, and Lincoln Rhyme, a disabled ex-head of NYPD forensics, by Jeffery Deaver

Simon “The Saint” Templar: international thief, millionaire, and master of disguise, by Burl Barer

Bernadette “Cat” Saint Clare: FBI agent with paranormal powers, in St. Paul, Minnesota, by Terri Persons

James Sakura: Japanese-American NYPD lieutenant in New York City, by Harker Moore

Cassandra (Cassie) Sales: 50 year-old housewife dealing with her workaholic wine importer husband’s stroke in Long Island, New York, by Leslie Glass

Gregory Sallust: British agent battling Nazis, sometimes by occult means, by Dennis Wheatley

Jane Salt: detective constable, and Frank Kavanagh, detective inspector, in Birmingham, England, by David Armstrong

Charles Salter: 40-something police inspector in Toronto, Canada, by Eric Wright

Terry Saltz: who lost his job, wife, truck, and mobile home, starting over as a pizza delivery driver in Spencer, Ohio, by L.T. Fawkes

Samejima: maverick police detective, in Tokyo, Japan, by Arimasa Osawa

Albert Samson: middle-aged, low-key private investigator, in Indianapolis, Indiana, by Michael Z. Lewin

Bernard Samson: 40-something British spy, based in London, England, by Len Deighton

Hannah Sampson: CSI diver in the British Virgin Islands, by Kathy Brandt

Lily Sampson: young American graduate student archeologist, in late 1930s and early 1940s Jerusalem and Morocco, by Aileen Baron

Jake Samson: ex-cop, and Rosie Vicente, a carpenter, in Berkeley, California, by Shelley Singer

John Samson: private investigator in London, England, by Miles Tripp

Robert Sand: the Black Samurai, trained for seven years by a Japanese samurai master, fighting to save the world from sinister threats, by Marc Olden

John Sanders: police detective, and Harriet Jeffries, a photographer, in Toronto, Ontario, Canada, by Sale, Medora

Abigail (Sandy) Sanderson: crisply efficient secretary to Robert (Robby) Forsyth, a retired barrister in London, England, by E.X. Giroux

Commander Joe Sandilands: Scotland Yard detective assigned to post-WWI India, by Barbara Cleverly

Police Inspector Sands: in Toronto, Canada, by Margaret Millar

Greer Sands: psychic and massage therapist with a teenage son, in fictional Shadow Hills, in the mountains above Los Angeles, California, by Shari Shattuck

Jake Sands: retired salvage agent and finder of lost things in Santa Barbara, California, by Ron Ely

Nikki Sands: in the Napa Valley, California, in the Wine Lovers mysteries by Michele Scott

George Sansi: half- English, half-Indian police inspector, in Bombay, India, by Paul Mann

Jock Sargeant: an ex-con framed for murder and a mysterious billionaire out for revenge, by Daniel da Cruz

Peter Cutler Sargeant II: public relations consultant in New York City, by Edgar Box

Libby Sarjeant: middle-aged actress and private investigator, in Kent, England, by Lesley Cookman

Vonna Saucier, and Delbert “Dub” Greenert, private investigators, in New Orleans, Louisiana, by J. Madison Davis

Myra Savage: by Mark McShane

Spencer Monroe Savage: US diplomat by Paul Theroux

Thornton Savage: police detective in New York City, by John Mackie

Dillon Savich and Lacey Sherlock, husband and wife FBI agents and computer specialists, mostly based in San Francisco, California, by Catherine Coulter

Justin Savile and Cuddy Mangum, police detectives in a small town in North Carolina, by Michael Malone

Pete (Pierre-Ange, Stone Angel) Sawyer: French-American private investigator in Paris, France, by Marvin Albert

Reyn Sawyer: sassy hair stylist in San Antonio, Texas, by Laura Bradley

Saxon: former US FBI agent turned true-crime writer, and Grace Fitzgerald, Detective Chief Superintendent with the murder squad, in Dublin, Ireland, by Ingrid Black

Saxon: actor and private eye in Los Angeles, California, by Les Roberts

Alan Saxon: professional golfer, by Keith Miles (Edward Marston)

Catherine Sayler: private investigator in San Francisco, California, by Linda Grant

Hillary Scarborough: a domestic artiste, and her assistant, Jane Ferguson, an ex-law student, in the Murder by Design series by Paula Carter

Hannah Scarlett: Detective Chief Inspector of the Cold Case Squad, and Daniel Kind, retired Oxford historian, in the Lake District of England, by Martin Edwards

Dr. Kay Scarpetta: chief medical examiner in Richmond, Virginia, by Patricia Cornwell

Lenny Schneider: hardboiled Jewish private investigator, based in New York City, by Ed Goldberg

Pete Schofield: private investigator, and his wife Jeannie, in Los Angeles, California, by Thomas B. Dewey

Shane Schofield: leader of a team of Marines, by Matthew Reilly

Inspector Schmidt: colorless cop with a brilliant mind, in New York City, by George Bagby (Aaron Mark Stein)

Joe “Shoe” Schumacher: ex-cop, professional wrestler, and bodyguard, in Vancouver, British Columbia, and Toronto, Ontario, Canada, by Michael Blair

Hubert Schuze: pot hunter and owner of a shop selling Native American pottery in Albuquerque, New Mexico, by J. Michael Orenduff

Dulcie Schwartz: Harvard doctoral candidate living in Cambridge, Massachusetts, and the ghost of her cat Mr. Grey, by Clea Simon

Ike Schwartz: sheriff in the small town, Picketsville, Virginia, by Frederick Ramsay

Rebecca Schwartz: Jewish feminist lawyer in San Francisco, California, by Julie Smith

Nicolette Scott: archaeologist in the southwestern USA, by Val Davis (Robert & Angie Irvine)

Philip Scott: by Hartley Howard (Harry Carmichael)

Shell Scott: ex-Marine private investigator, in Los Angeles, California, by Richard Prather

Matt Scudder: reformed alcoholic and unlicensed private eye, in New York City by Lawrence Block

Shane Scully: police sergeant in Los Angeles, California, by Stephen J. Cannell

Simon Serrailler: police Chief Inspector in Lafferton, England, by Susan Hill

Caleb Shaw, Oliver Stone, Milton Farb, and Reuben Rhodes: The Camel Club, a group of four dysfunctional men who investigate political conspiracies, and honorary member Alex Ford, a Secret Service agent, in Washington, DC, by David Baldacci

Sean “NMI” Sean: private investigator in Hennepin County, Minnesota, by Carl Brookins

Silas Seaweed: a Coast Salish Aboriginal beat cop on the streets of Victoria, British Columbia, Canada, by Stanley Evans

Gordon Seegerman: reluctant public defender by day and lead singer in a Barry Manilow cover band by night, in northern California, by Dylan Schaffer

Libby Seale: a seamstress from New York, and newspaper reporter Peter Eberle, in 1894 Portland, Oregon, by M.J. Zellnik

Alexander Seaton: schoolmaster in 1620s Banff and Aberdeen, Scotland, by Shona MacLean

Miss Emily D. Seeton: retired British art teacher in Kent, England, by Heron Carvic

Claudia Seferius: vineyard owner in 1st century Rome, Italy, by Marilyn Todd

Nicholas Segalla: time-traveling scholar in England, by Ann Dukthas (Paul Doherty)

Mavis Seidlitz: blonde private investigator with Gracie Allen tendencies, by Carter Brown

Inspector Konrad Sejer: working in a small mountain village in Norway, by Karin Fossum

Gerhard Self: former public prosecutor during the Nazi era, now a private investigator in his late 60s, in 1980s Mannheim, in the newly unified Germany, by Bernhard Schlink

Sara Selkirk: renowned cellist, in Bath, England, by Morag Joss

Joe Serpe: disgraced NYPD narcotics detective, now driving a heating oil delivery truck and doing some private investigating with his nemesis Bob Healy, the retired Internal Affairs officer, in New York City, by Tony Spinosa (Reed Farrel Coleman)

Brano Sev, Emil Brod, Ferenc Kolyeszar, and other police and intelligence agents in Communist-era Eastern Europe, by Olen Steinhauer

Grady Service: Department of Natural Resources Conservation Officer, in the Upper Peninsula of Michigan, in the Woods Cop series by Joseph Heywood

Frank Sessions: homicide detective lieutenant, Manhattan North, in New York City, by Hillary Waugh

Mick Sever: rock and roll journalist, by Don Bruns

Dr. Grace Severance: retired pathologist in Arizona, by Margaret Scherf

Knute Severson: police detective in Boston, Massachusetts, by Tobias Wells (Stanton Forbes)

Sewell, Hitchcock, a certified mortician in Baltimore, Maryland by Tim Cockey

Annie Seymour: police reporter in New Haven, Connecticut, by Karen E. Olson

Seymour, Sando: a multilingual officer with Special Branch in 1906 Trieste in the Austro-Hungarian Empire by Michael Pearce

Rene Shade: ex-boxer, now a police detective, in the bayou town St. Bruno, Louisiana, by Daniel Woodrell

Ron Shade: tough-guy private investigator with a soft heart, and a martial arts expert, in Chicago, Illinois, by Michael A. Black

Shader, Dr. Susan: a psychiatrist and criminal profiler in Chicago, Illinois by Joseph Glass

“The Shadow”, a private investigator in the USA by Maxwell Grant

Shaft, John: a tough, black private detective in New York, New York by Ernest Tidyman

Shakespeare, Young Will:   a writer, the Elizabethan era's answer to Sherlocke Holmes, in London, England by Simon Hawke

Shallot, Sir Roger: agent of Cardinal Wolsey in England by Michael Clynes

Alex Shanahan: general manager of Majestic Airlines, in Boston, Massachusetts, and elsewhere, sometimes undercover investigator in the airline industry, and later a private investigator, by Lynne Heitman

Dietrich “Deets” Shanahan: 70-something former Army intelligence officer and semi-retired private investigator, in Indianapolis, Indiana, by Ronald Tierney

Shandy, Helen Marsh: librarian and wife in Balaclava County, Massachusetts by Charlotte MacLeod

Shandy, Peter: college botany professor and husband in Balaclava County, Massachusetts by Charlotte MacLeod

Randall Shane: ex-FBI agent and expert in child abductions, by Chris Jordan (W.R. Philbrick)

Shannon, John: ex-NYPD detective turned special agent (code-name “Shango”) by Clyde W. Ford

Shannon, John J.  by Cleve F. Adams

Rick Shannon: FM rock disc jockey and private investigator in the Mississippi Delta, by Bill Fitzhugh

Shapiro, Desiree: a 5' 2" queen-sized private investigator in New York, New York by Selma Eichler

Shapiro, Frank: a cop in Castlemer, England by Jo Bannister

Nathan Shapiro: Jewish cop usually working in homicide under Bill Weigand, in New York City, by Richard & Frances Lockridge

Simon Shard: Detective Chief Inspector at Scotland Yard, in London, England, by Philip McCutchan

Matthew Shardlake: lawyer in mid-16th century England,by C.J. Sansom

Sharman, Nick: hard-living ex-cop PI in London, England by Mark Timlin

Nayir Sharqi: a Palestinian-Bedouin desert guide, and Katya Hijazi, a forensic scientist, in Jeddah, Saudi Arabia, by Zoë Ferraris

Ray Sharp: American expatriate journalist and detective, in east Asia, by Eric Stone

Karen Sharpe: detective constable, later detective sergeant, in 1990s Yorkshire, England, by John Connor

Sharples, Claire: a microbiologist in the San Joaquin Valley, California by Rebecca Rothenberg

Shaw: an operative for a secret global intelligence agency, and Katie James, a disgraced investigative journalist, by David Baldacci

Shaw, Abby: leaving behind a career in corporate law and a cheating husband, returns to her hometown of Paradise, Colorado to take over her aunt's candy shop, Divinity by Sammi Carter

Cassidy Shaw, a reporter, Allison Pierce, a federal prosecutor, and Nicole Hedge, an FBI special agent, in the Triple Threat series, by Lis Wiehl and April Henry

Esmonde Shaw: Commander in the English Naval Intelligence Division, later with a semi-official intelligence agency called 6D2, by Philip McCutchan

James Shaw: Jewish private investigator in New York City, by Isidore Haiblum

Shaw, Samantha: a suburban housewife and soccer mom in Southern California by Jennifer Apodaca

Shaw, Paul: a private investigator in New York by Mark Sadler

Peter Shaw, detective inspector, and George Valentine, detective sergeant, in Norfolk, England, by Jim Kelly

Shaw, Simon: professor of history in Raleigh, North Carolina by Sarah R. Shaber

Hector Belascoaran Shayne: one-eyed, half-Irish, half-Basque, Coca-Cola-swilling private investigator in Mexico City, by Paco Ignacio Taibo II

Shayne, Michael: this page contains all books by all authors

Shayne, Michael: a series character by Davis Dresser as Brett Halliday

Shayne, Michael: a series character by Robert Terrall as Brett Halliday

Sheldon, Graham: cop and boyfriend by Aaron Elkins

Dan “Spider” Shepherd: former SAS trooper turned undercover cop, based in London, England, by Stephen Leather

Shepard, J.: a lawyer who surfs in Christianitos, California by John DeCure

Robert Sherard: great-grandson of Wordsworth, and Oscar Wilde, poet, wit, and playwright, friend of Arthur Conan Doyle, investigate murders in Victorian England, Scotland, and France, by Gyles Brandreth

Archie Sheridan: police detective, and Gretchen Lowell, a serial killer who tortured and released him, in Portland, Oregon, by Chelsea Cain

Sheridan, Dan: an attorney in Boston, Massachusetts by Barry Reed

Sheringham, Roger: a writer who is an obnoxious sleuth by Anthony Berkeley

Sherman, Winston Marlowe: a professor in Aisley, New York by M. K. Lorens

Sherlock, Lacey: a FBI special agent in Washington D.C. by Catherine Coulter

Sherwood, Payton: a private investigator in the East Village of New York City, New York by Russell Atwood

Jefferson Shields: private detective in 1960s Australia, by Patricia Carlon

Shigata, Mark: a Japanese-American ex-FBI agent turned sheriff in Bayport, Texas by Anne Wingate

Shimura, Rei: a teacher and antiques dealer in Tokyo, Japan by Sujata Massey

Shipton, Cassandra: owner of Earthlore Herbal Preparations and Cruelty-Free Cosmetics, and a member of a study group turned coven by Dolores Stewart Riccio

Ben Shock and Charity Tucker, unlicensed private investigators in the 1970s, by Patrick Buchanan (Edwin Corley)

Shore, Jemima: investigative television journalist in London, England by Antonia Fraser

Shore, Marla: a beauty salon owner in Southern Florida by Nancy Cohen

Chris Shovelin: down-at-the-heals 50-something British private investigator, in California and Kenya, by Julian Rathbone

Shugak, Kate: native Alaskan ex-DA investigator, who lives on a 160-acre homestead in a generic national Park in Alaska with her half-wolf, half-husky dog named Mutt

Sidden, Jo Beth: a bloodhound trainer and tracker in Georgia by Virginia Lanier

Isaac Sidel: deputy police commissioner, later Mayor, in New York City, by Jerome Charyn

Siegel, Phoebe: a private investigator in Billings, Montana by Sandra West Prowell

Omar Yussef Sihran: 50-ish schoolteacher in a Palestinian refugee camp, living in Bethlehem, Palestinian Authority, by Matt Beynon Rees

Silence, John: a physician in England by Algernon Blackwood

Fiona Silk: talent-challenged romance writer, in the bilingual tourist town St. Aubaine, Quebec, Canada, by Mary Jane Maffini

Silva, Joe: a police chief in Mellingham, Massachusetts by Susan Oleksiw

Mario Silva: chief inspector for criminal matters of the federal police, in Brazil, by Leighton Gage

Silver, David: homicide cop with an alien partner in the U.S.A. by Lynn S. Hightower

Silver, Emily: an actress in New York, New York by  Carol Brennan

Silver, Miss Maud: a retired governess and teacher who becomes a professional private detective in London, England by Patricia Wentworth

Abby Silvernale: newly-widowed thirty-year old waitress in upstate Bantam, New York, by Julia Pomeroy

Guy Silvestri: police detective in Massachusetts, by Maggie Rennert

Bernie Simmons: assistant district attorney in New York City, by Richard & Frances Lockridge

Bernie and Libby Simmons: caterers in Longely, New York, in the Mystery with Recipes series by Isis Crawford (Barbara Block)

Simon, Grant: by Hugh Pentecost

Simon, Margo: California Public Radio reporter in San Diego, California by Janice Steinberg

Simpson, Arthur Abdel: comic rogue and petty crook in England by Eric Ambler

Oliver Simpson: Detective Inspector, and Philipa Lowe, an amateur sleuth, in England, by Roger Omerod

Simpson, Tim: a financial consultant turned art investment specialist in London, England by John Malcolm

Abby Sinclair: freelance security consultant who hunts stalkers, and Tess McCallum, an FBI special agent, in Los Angeles, California, by Michael Prescott

Sinclair, Cecily: Edwardian hotel owner in Badger's End, England by Kate Kingsbury

Sinclair, Chris: a district attorney in San Antonio, Texas by Jay Brandon

Sinclair, Evangeline: an actress in London, England by Marian Babson

Sinclair, Matthew Arthur: a gay epileptic D. A. turned store owner in New Orleans, Louisiana by Tony Fennelly

Sinclair, Mort: a respected genealogist and lawyer on Fogge Island off the New England Coast by Gene Stratton

John “Chant” Sinclair: Medal of Honor winner in Vietnam and martial arts master turned artist by George Chesbro

Tori Sinclair: a Yankee librarian moving to Sweet Briar, South Carolina, in the Southern Sewing Circle mysteries by Elizabeth Lynn Casey (Laura Bradford)

Tucker Sinclair: 30-something divorcee and financial adviser, in Los Angeles, California, by Patricia Smiley

Singer, Jacob: a 1940s Hollywood private eye in Los Angeles, California by George Baxt

Singer, Judith: a resident of Long Island, New York by Susan Isaacs

Inspector Singh: police inspector based in Singapore, by Shamini Flint

Sixsmith, Joe: private detective in England by Reginald Hill

Skeehan, Georgia: a rookie fire marshal in New York, New York by Suzanne Chazin

Skellar, Samantha: FBI Agent on the trail of a possible serial killer who has been terrorizing the suburban neighborhoods of Seattle, Washington by Lynne Jamneck

Skinner, Robert: a high-ranking cop in Edinburgh, Scotland by Quintin Jardine

Max Skull: movie director, and Margot O’Banion, a film editor, based in Los Angeles, California. by Kit Sloane

Anthony Slade: Superindendent at Scotland Yard, in London, England, by Leonard Gribble

Jo Slater: sociopathic socialite in New York City, by Jane Stanton Hitchcock

Slider, Bill: police inspector in London, England by Cynthia Harrod-Eagles

Boris Slivka: hard-drinking screenwriter, and his partner Larry Baker, in Hollywood, California, by Carter Brown

Aggie Sloan-Wilcox: wife of the minister of the Consolidated Community Church, in Emerald Springs, Ohio, in the Ministry Is Murder series by Emilie Richards

Sloan, Charley: criminal attorney in Detroit, Michigan by William J. Coughlin

Sloan, Christopher Dennis "Seedy:" Berebury CID department head in West Calleshire, England by Catherine Aird

David Sloane: lawyer in Seattle, Washington, by Robert Dugoni

Sloan, Duncan: a private investigator in Florida by Bob Truluck

Dr. Mark Sloan: Chief of Internal Medicine at Community General Hospital who consults with the LAPD, in Los Angeles, California, in the Diagnosis Murder TV novelizations by Lee Goldberg

Sloan, Sydney: a lesbian private investigator in New York, New York, in the Stonewall Inn mysteries by Randye Lordon

Slocombe, Drew: former nurse who has become an undertaker in Bradbourne, England by Rebecca Tope

Small, David: rabbi sleuth in Barnard's Crossing, Massachusetts by Harry Kemelman

Small, Jake: Constable in 1940s Canadian police officers in Fort York, Ontario by A. E. Eddenden

Smiley, George: British Intelligence agent and scholar in London, England by John Le Carre

Danny Smiricki: jazz saxophone player, teacher, and observer of post-WW2 life in Czechoslovakia and Canada, by Josef Škvorecký

Smith, Bill: 40-something Army brat PI in New York by S. J. Rozan

Smith, Brad: championship tennis player and part-time CIA agent in the United States by Jack Bickham

Smith, Cellini: an accountant for the Mob in New York, New York, turned honest private investigator in Los Angeles, California by Robert Reeves (born 1912)

Stevens, Delta [Storm], a police officer in River Valley, California near Los Angeles by Linda Kay Silva

Smith, Grace: a private investigator in Seatoun, England by Liz Evans

Smith, Jill: homicide detective in Berkeley, California by Susan Dunlap

Smith, Dr. John: by Hugh Pentecost

Smith, Mackenzie: law professor in Washington, D.C. by Margaret Truman

Smith, Marguerite: a retired science teacher in Cape Cod, Massachusetts by Marie Lee

Molly Smith: rookie constable, and Sergeant John Winters, in the mountain town Trafalgar, British Columbia, Canada, by Vicki Delany

Smith, (Nicole) Nickel: avowed lesbian and small-town newspaper editor in Runnymeade by Rita Mae Brown

Owen Smith: detective chief superintendent at Scotland Yard, in London, England, by James Barnett

Smith, Sloan: assistant to Bedford Green, an art gallery owner in Greenwich Village, New York, in 1925  by Michael Kilian

Smith, Truman: private eye in Galveston, Texas by Bill Crider

William Wilberforce Smith: an aristocratic Caribbean operative in the fictitious Security Executive, a British military intelligence organization, by William Haggard

Smith, Zachariah: private investigator in Oregon by L. L. Thrasher

Smithsonian, Lacey: the "Crime of Fashion" columnist in Washington D. C. by Ellen Byerrum

Smythe, Tuck: aspiring actor, the Elizabethan era's answer to Holmes' Dr. Watson, in London, England by Simon Hawke

Terry Sneed: unscrupulous Scotland Yard inspector, based in London, England, by G.F. Newman

Snow, John: a young, retired superintendent of Scotland Yard by Raymond Sawkins

Snow, Morgan: a sex therapist in the Butterfield Institute in New York City by M. J. Rose

Dr. Robert Snow: at a psychiatric hospital in Baltimore, Maryland, and then Vancouver, British Columbia, Canada, by David Laing Dawson

Socarides, Aristotle Plato: ex-cop part-time fisherman P.I. in Cape Cod, Massachusetts by Paul Kemprecos

The Social Club Mysteries in Borderville, Virginia by Graham Landrum

Sokol, Pauline: ex-nurse, now an investigator of medical fraud by Lori Avocato

Solano, Lupe: private investigator in Miami, Florida by Carolina Garcia Aguilera

Solomon, Bretta: the 45 year old owner of the Flower Shop in River City, Missouri, in The Gardening Mysteries by Janis Harrison

Solomon, Sasha: a public relations director in New Mexico by Pari Noskin Taichert

Squabbling lawyers Steve Solomon, a Coconut Beach bum and Victoria Lord, a Miami blue blood, in Florida by Paul Levine

Sonia Someth: owner of Stellar Investigations Detective Agency, and a master of Verdic astrology, in Pune, India, by Manjiri Prabhu

Harry Sommers: former bouncer and con man, now a private investigator, based in London, England, by Peter Whalley

Sorby, Helen: a social worker in 1905 in Pittsburgh Pennsylvania by Karen Rose Cercone

Source, Devlin: a police detective sergeant in Baltimore, Maryland by James Grady

Southwell, Robert: a detective chief inspector in York, England by Barbara Whitehead

Southwood, Anna: a private enquiry agent in Sidney, Australia by Jean Bedford

Space, Sam: a private investigator on Mars by William F. Nolan

Ben Spanner and H.J. Mavity, ex-spouses in Connecticut, by Ron Goulart

Sparrow, Charlie: a tough,  smart-aleck spy who is irresistible to women in the USA by Tom Ardies

Aelius Spartianus: former soldier, now historian to Diocletian, in early 4th century Rome, by Ben Pastor

Spearman, Henry: an economics professor at Harvard in Cambridge, Massachusetts by Marshall Jevons

Speed, Diana: a publishing company chief financial office in New York, New York by Tony Gibbs

Speeter, Axel: one of a group of small town gamblers in Minnesota by Peter Hautman

Isabele “Izzy” Spellman: 28-year old sleuth working for her parents’ private investigation firm, in San Francisco, California, by Lisa Lutz

Philip Spence: artist, and Margo Franklin, a waitress, in Chicago, Illinois, by Jerry B. Jenkins

Suzy Spencer: a working mother and part-time television producer, in the village of Tarnfield in the north of England, in the Norbridge Chronicles, by Lis Howell

Spenser: ex-boxer, ex-state cop turned private eye in Boston, Massachusetts by Robert B. Parker

Spencer, Joan: symphony orchestra manager in Oliver, Indiana by Sara Hoskinson Frommer

Spotted Moon, Charles: an attorney & Ojibway tribal shaman in San Francisco, California by Chelsea Quinn Yarbro

Spraggue, Michael III: wealthy actor and ex-PI in Boston, Massachusetts by Linda Barnes

Spring, Penny: a 60-something anthropologist in Cambridge, England by Margot Arnold

Cole Springer: former Secret Service agent and saloonkeeper, in Aspen, Colorado, by W.L. Ripley

Springer, Dan: a writer for a magazine in Las Vegas, Nevada by L.C. Hayden

Maddie Springer: shoe designer turned crime fighter, in Los Angeles, California, in the High Heels romantic mysteries by Gemma Halliday

Judd Springfield: police chief in Coolidge Corners, Vermont, by Alison Smith

Dolly Madison (Maddy) Sprowls: 60-something newspaper archivist for the Herald-Union, and cub reporter Aubrey McGinty, in Hannawa, Ohio, in the Morgue Mama mysteries by C.R. Corwin

Jeremiah Spur: retired white Texas Ranger, and Clyde Thomas, the first black deputy sheriff, in Brenham, Texas, by James Hime

Squires, Lee: an English professor and poet in Montana by Christine Andreae

Riley Spartz: investigative TV reporter, in Minneapolis, Minnesota, by Julie Kramer

Giff Speer: master sergeant and undercover agent in the US Army Military Police, around the USA, by Don Tracy

Bruno Stachel: the German flying ace from WWI to 1945, by Jack D. Hunter

Nadia Stafford: ex-cop turned hitwoman, in Ontario, Canada, by Kelley Armstrong

David Stark: police inspector in England, by Keith Wright

Harry Stark: curmudgeonly homicide detective who listens to jazz and has a reclusive cat, in Toronto, Ontario, Canada, by John Worsley Simpson

Harry Starks: charismatic homosexual gangster in 1960s London, England, by Jake Arnott

Jason Starr, a genius and discredited scientist, and Adam Cyber, a superman from the future, by Peter Heath

Inspector Starrett: of the Garda Serious Crime Unit, in County Donegal, Ireland, by Paul Charles

T.D. Stash: unlicensed private investigator, in Florida, by W.R. Philbrick

Charles St. Clair: journalist in 1870s New York City, by Allan Levine

St. Cyr, Jean-Louis: French police inspector in 1940s Paris, France by J. Robert Janes

Sebastian St. Cyr: Viscount Devlin, an investigator in Regency England, by C.S. Harris

Valentin St. Cyr: Creole private detective in the early 20th century, in the Storyville district of New Orleans, Louisiana, by David Fulmer

Jackson Steeg: suspended cop with a drinking problem, in Hell’s Kitchen, New York City, by Ira Berkowitz

Ted Stephens: homicide detective sergeant in Houston, Texas, by Bill Crider and Clyde Wilson

Philip St. George: Satan Sleuth, by Michael Avalone

St. George, Sweeney: an art history professor specializing in representations of death, in Byzantium, Vermont by Sarah Stewart Taylor

Marty Stiles, an ex-NYPD cop turned PI, and his assistant Alessandra (Al) Martillo, by Norman Green

St. Ives, Philip: a professional go-between by Oliver Bleeck

Alex St. James: TV reporter based in Chicago, Illinois, by Julie Hyzy

St. James, Quin: part of a wife & husband P.I. team by T. J. MacGregor

St. John, Jeremiah: private investigator in San Francisco, California by William Babula

St. Jones, Revelations: a private investigator in the manner of Sam Spade and Phillip Marlowe, in San Francisco, California by Barry Shannon

Detective Chief Inspector St. Just of the Cambridgeshire Constabulary and Sergeant Fear, in England, by G.M. Malliet

St. Mars, Gideon: a viscount who becomes the highwayman Blue Satan, and his friend Mrs. Kean, in early 18th century England, by Patricia Wynn

Michael St. Pierre: master thief nearing retirement, operating in Europe, by Richard Doetsch

Stackhouse, Sookie: a cocktail waitress and her vampire boyfriend, Bill, in small town Louisiana by Charlaine Harris

Stanhope, Rachel a birder (birdwatcher) in the Rocky Mountain National Park, in Colorado by Christine Goff

Inez Stannert: saloon owner, around 1880 in Leadville, Colorado, in the Silver Rush mysteries by Ann Parker

Starbranch, Harry: a burned-out Denver cop turned small-town police chief in Victory, Wyoming by Gregory Bean

David Stark: American attorney, and Liu Hulan, a Chinese police inspector, combining talents to solve mysteries in China, by Lisa See

Stark, Joanna: Art Security Expert in San Francisco, California by Marcia Muller

Stark, Malvin: a nerdy, unsuccessful real estate agent, an alias for Gil Yates, private investigator in Los Angeles, California by Alistair Boyle

Stark, Michael, oversexed, handsome heir-apparent to a herpes ointment fortune in New York by David Stukas

Morgan Stark: black mercenary soldier, and Felicity O’Brian, an Irish jewel thief, by Austin S. Camacho

Robert Stark: private investigator, by Mark Schorr

Starkey, Dan: journalist in Belfast, Northern Ireland by Colin Bateman

Maggie Starr: America’s most famous ex-striptease artist, running her late husband’s newspaper syndicate, and her stepson Jack, her VP and chief troubleshooter, in 1948 Manhattan, New York City, by Max Allan Collins

Richard Steel: widowed burned-out ER doctor with a teen-age son, and world-renowned geneticist Kathleen Sullivan, in New York City, by Peter Clement

Stefano, Nick: a 50s bartender and private eye in Washington D.C. by George P. Pelecanos

Elliot Steil: son of an American sugar magnate, later a professor of English at a Cuban college and then working in an import-export business, in Havana, Cuba, by José Latour

Stein, Gertrude: expatriate writer in Paris in the 20s by Walter Satterthwait

Stella the Stargazer, an astrologer and lovelorn columnist in Denver, Colorado by Christine T. Jorgensen

Sterling, Paisley: an author of children's books in Rowan Springs, Kentucky by E. Joan Sims

Stevens, Grace, a cop in Seattle, Washington by Lowen Clausen

Ted Stevens: hard-luck attorney, and his law partner Paul Morganstein, in Tallahassee, Florida, by Terry Lewis

Stewart, Blaine: an ex-cop turned private investigator in New York, New York by Sharon Zukowski

Stewart, Kellen: a therapist and a lesbian in Great Britain by Manda Scott

Stewart, Maggie: an interior decorator in South Carolina: Shirley Robertson

Neville Stewart: detective inspector, Mark Lombardi, police officer, and Callie Anson, a newly ordained Anglican cleric, in London, England, by Kate Charles

Stewart, Teal: a Certified Public Accountant in Boston, Massachusetts by J. Dayne Lamb

Ernest "Stick" Stickley: ex-con in Detroit, Michigan, by Elmore Leonard

Hanno Stiffeniis: magistrate in the Napoleonic era, in early 1800s Konigsberg, Prussia, by Michael Gregorio

Derek Stillwater: a bioterrorism expert with the US Department of Homeland Security, by Mark Terry

Stock, Matthew: 17th century town constable and clothier in Chelmsford, England by Leonard Tourney

Raine Stockton: who runs a dog boarding and training facility and consults for the the Forest Service after being downsized in a budget cut, and her golden retriever Cisco, in the Smoky Mountains of Hanover County, North Carolina, by Donna Ball

Stone, Jesse: Homicide Detective in Paradise, Massachusetts by Robert B. Parker

Stone, Lucy: sleuthing wife and mother of four in Tinker's Cove, Maine by Leslie Meier

Stone, Michael: forensic psychologist in Vermont by Anna Salter

Stone, Nick: an S.A.S. agent by Andy McNab

Oliver Stone, Milton Farb, Caleb Shaw, and Reuben Rhodes: The Camel Club, a group of four dysfunctional men who investigate political conspiracies, and honorary member Alex Ford, a Secret Service agent, in Washington, DC, by David Baldacci

Stone, Sergeant: a village detective in Allshire, England by Sarah J. Mason

Stoner, Harry: private investigator in Cincinnati, Ohio by Jonathan Valin

Strachey, Donald: a gay private investigator, in Albany, New York by Richard Stevenson

Strange, Brenda: a private investigator of the weird in Tampa, Florida by Patty Henderson

Strange, Derek: black and successful is an ex-cop turned private investigator in Washington D. C. by George P. Pelecanos

Strange, Sylvia: a forensic psychologist in Santa Fe, New Mexico by Sarah Lovett 

Strangeways, Nigel: an Oxford graduate in England by Nicholas Blake

Ted Stratton: detective inspector in 1940s London, England, by Laura Wilson

Streeter: a bounty hunter and private eye in Denver, Colorado by Michael Stone

Dave Strickland: private investigator in San Jose, California, by Thomas D. Davis

Eric Stride: police inspector with the Newfoundland Constabulary, in late 1940s St. John's, Newfoundland, before confederation with Canada, by Thomas Rendell Curran

Jonathan Stride: detective lieutenant in Duluth, Minnesota, by Brian Freeman

Jonce Striker: founder of Investigative Services, Inc., and Natasha Chamberlain, a young investigator, in Knoxville, Tennessee, by Christy Tillery French

String: an alien Ilaki, partners with a homicide cop, in the U.S.A. by Lynn S. Hightower

Jim Stringer: railroad worker and amateur sleuth in the early 1900s, in England, by Andrew Martin

Fleming Stone: bookish private investigator, frequently called in to help the police solve a crime, in New York City, by Carolyn Wells

Storme, Wyatt: ex-NFL star, private investigator and Vietnam vet in N. Branson, Missouri by W. L. Ripley

Strong, Lydia: a true crime author in Santa Fe, New Mexico by Lisa Miscione

Dixie T. Struthers: detective sergeant in the early days of Silicon Valley (late 1980s), in San José, California, by L.V. Sims

John Stryker: detective sergeant in Los Angeles, California, by Dallas Barnes

Stuart, Jane: a widowed literary agent in Shady Hills, New Jersey by Evan Marshall

Stuart, Lizabeth “Lizzie”: a 38 year old African-American professor of crime historian in Virginia by Frankie Y. Bailey

Stubbs, Rosemary: a chaplain at Sanderson College in the Connecticut River Valley in Massachusetts by Clare Munnings

Adam Stubø: detective inspector, and Johanne Vik, an Oslo University psychology professor and former FBI profiler, in Oslo, Norway, by Anne Holt

Jakob Studer: police sergeant (Wachtmeister) in 1930s Bern, Switzerland, by Friedrich Glauser

Styles, Peter: an investigate reporter by Judson Philips

Sueno, George: a military police officer in South Korea by Martin Limon

Sughrue, C. W.: ex-Army spy turned private eye in Montana James Crumley

Sullivan, Carolyn: a part-time law student and overworked probation officer in Ventura County, California by Nancy Taylor Rosenberg

Giles Sullivan: retired attorney, and Isabel Macintosh, a faculty dean, in Vermont, in the Crossword Puzzle mysteries by Herbert Resnicow

Sullivan, Liz: freelance writer and organic gardener in Palo Alto, California by Lora Roberts

Mac Sullivan: retired cop, and Whiskey, his Irish Wolfhound partner, along with Rachel Brenner, a 40-something divorcee and mother of a teenaged son, in Washington, DC, by Evelyn David

Sullivan, Rob: British Customs officer in Brussels, Belgium by Paul Adam

Summer, Maggie: owner of the  antique print business named Shadows in Maine by Lea Wait

Sumuru: a master plotter working towards world dominance, by Sax Rohmer

Dr. Evelyn Sutcliffe: emergency room physician at Manhattan Hospital, in New York City, by Leah Ruth Robinson

Erlendur Sveinsson: detective inspector, and his colleagues Sigurdur Oli and Elinborg, in Reykjavik, Iceland, by Arnaldur Indridason

Svenson, Mike: a police officer in Grantham, Oklahoma by Eve K. Sandstrom

Swagger, Bob “the Nailer” master sniper in the United States by Stephen Hunter

A.P. “Ape” Swain: free-lance international agent mostly in the Middle East, by Daniel da Cruz

Bert Swain: divorced middle-aged writer and head of public relations at a Manhattan medical research center, in New York City, by Paul Nathan

Swann, Cassie: professional bridge player, Bellington, England by Susan Moody

Henry Swann: private investigator subsisting on skip-tracing in Manhattan, New York City, by Charles Salzberg

Sweeney, Nell: a governess in post-Civil-War Boston, Massachusetts by P. B. Ryan

Sweetwater, Caleb: a policeman in New York by Anna Katherine Green

Swensen, Hannah: the manager of The Cookie Jar in Lake Eden, Minnesota by Joanne Fluke

Eleanor Swift: owner of pizza restaurant “A Slice of Delight” in Timber Ridge, North Carolina, by Chris Cavender (Tim Myers)

Swift, Jamie: an editor of a newspaper in Beaumont, South Carolina by Janet Evanovich with Charlotte Hughes

Loren Swift: laid-back Vietnam veteran private investigator, in Charlottesville, Virginia; Steven Kirk, a burned-out CIA agent, in Charlottesville, Virginia, by Doug Hornig

Swift, Sabina: a detective agency owner in Washington D. C. by Dorothy Sucher

Swinbrooke, Kathryn: 15th century physician, apothecary, death investigator in Canterbury, England by C. L. Grace

Bert Swinton: intuitive detective inspector in Sydney, Australia, by Pat Flower

Swithin, Oliver: a children's book author in Great Britain by Alan Beechey

Swyteck, Jack: a criminal defense lawyer in Miami, Florida by James Grippando

Szabo, Annie: a writer, mother and widow by Meredith Blevins

Szabo, Zoe: former Rolling Stone reporter tuned small town reporter in New England by Lisa Kleinholz